Summary of "Myasthenia Gravis - symptoms, pathophysiology, investigations, treatment"

Myasthenia Gravis is an autoimmune disorder affecting neuromuscular transmission, causing weakness in various muscles including eyes, limbs, and respiratory muscles.

The autoimmune attack occurs at the neuromuscular junction, where acetylcholine is released to stimulate muscle contraction.
The disorder is characterized by antibodies against acetylcholine receptors, leading to muscle fatigue and weakness.
Myasthenia Gravis can also be caused by certain medications.
Clinical features include fluctuating weakness, ptosis, diplopia, and respiratory muscle weakness.
Myasthenia crisis is a medical emergency requiring intubation or ventilation.
The disease has three stages: active phase, stable phase, and remission phase.
Investigations for Myasthenia Gravis include the ice pack test, tensilon test, EMG, and serological tests for antibodies.
Differential diagnoses include Lambert-Eaton syndrome, botulism, Guillain-Barre syndrome, and motor neuron disease.
Management includes awareness of medications, thymectomy, immunosuppressive agents, intravenous immunoglobulins, plasmapheresis, and acetylcholinesterase inhibitors.