Summary of Development of the Teeth

Key Concepts and Stages of Tooth Development:

Odontogenesis: The process of tooth development, which begins in utero.
Deciduous Teeth: Develop from weeks 6 to 7 of intrauterine life.
Permanent Teeth: Begin developing at week 14 of intrauterine life and continue until approximately 5 years after birth.
Tissue Components:
- Primitive Oral Epithelium: Derived from ectoderm.
- Dental Mesenchyme: Derived from craniofacial neural crest cells.
Development Process:
- Primary Epithelial Bands: Thickening of the oral epithelium that splits into two laminae (dental lamina and vestibular lamina).
- Dental Placodes: Localized projections that form as signal proteins (FGFs, BMPs, Ectodisplasin) induce cell proliferation and invagination.
- Morphogenesis Stages:
  - Bud Stage: Formation of the tooth bud from Dental Placodes.
  - Cap Stage: Development of the enamel organ with three types of epithelial cells (inner enamel epithelium, outer enamel epithelium, and stellate reticulum).
  - Bell Stage: Final shape determination of the crown and differentiation of specialized cells (ameloblasts and odontoblasts).
- Root Formation: Initiated by the cervical loop cells forming Hertwig's epithelial root sheath, guiding root development and inducing odontoblast differentiation.
- Epithelial Pearls: Residual epithelial cells that can lead to dental abnormalities.

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