Summary of "What is Synthetic Biology?"
Key concepts
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Life vs. non-life Both living and non-living matter are made of atoms and chemicals. Living systems are distinguished by how those atoms are organized into complex biological molecules and interactive systems.
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DNA as the informational molecule DNA’s double helix carries a four-letter chemical alphabet — A, C, T, G — that encodes instructions for growth, reproduction, and development.
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Genome The genome is the complete DNA sequence of an organism. “Reading a genome” refers to sequencing that complete DNA sequence.
Discoveries and advances
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Genome sequencing progress Scientists learned to read entire genomes across many organisms, from bacteria to fruit flies to humans.
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Gene transfer and genetic modification Individual genes (for example, a gene that causes jellyfish to glow) can be moved into other organisms to confer new traits.
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Synthetic biology A newer field that moves beyond reading and editing genomes to designing and writing genomes and creating new biological systems:
Synthetic biology is a new field that goes beyond reading and editing genomes to designing and writing genomes to create new biological systems.
- Genome synthesis and reconstruction Researchers have rewritten and rebuilt the entire genome of yeast and plan to insert that synthetic genome into a cell to “boot” it and produce a living organism. Conceptually, a successfully booted synthetic genome could create an organism discontinuous from the existing evolutionary chain — a life form based on a human-designed genome.
Methodology (typical sequence)
- Sequence/read genomes (genome sequencing).
- Modify or transfer genes between organisms (genetic engineering).
- Design and synthesize entire genomes (genome writing/reconstruction).
- Insert the synthetic genome into a cell and attempt to “boot” it so it becomes a living, reproducing organism.
Ethical and conceptual questions raised
- How far should this technology go?
- What are the implications of creating organisms deliberately different from any that have evolved?
Researchers / sources featured
- Drew Endy (Stanford professor)
Category
Science and Nature
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