Summary of Methylene Blue: Dosing Expert Pharmacist Dr. Newville

Main Ideas and Concepts

Methylene Blue Concentration:
A 1% solution of Methylene Blue contains 10 milligrams per milliliter (mg/mL).
Drop Calculation:
- 20 drops/mL: Each drop contains 0.5 mg of Methylene Blue.
- 15 drops/mL: Each drop contains approximately 0.66 mg of Methylene Blue.
Dosing Guidelines:
Recommended dosing ranges from 0.5 mg to 4 mg per kilogram of body weight daily.

For a person weighing 220 lbs (100 kg):
- At the lowest dose (0.5 mg/kg): Requires 50 mg, which translates to 100 drops (using the 20 drops/mL calculation).
- At the highest dose (4 mg/kg): Requires 400 mg, translating to 800 drops, which is impractical.
Considerations for Use:
- USP Grade: It's important to ensure that the Methylene Blue is USP Grade to minimize impurities.
- Cost-effectiveness: Consider whether the product is truly cost-effective, especially if high doses are needed.
Therapeutic Dosing:
While low doses may be used, achieving therapeutic benefits often requires higher dosing, balancing the potential benefits against side effects.