Nattokinase | Serrapeptase | Lumbrokinase: From Novice To Expert, All Your Questions Answered & More

Key wellness strategies, self-care techniques, and productivity-adjacent tips

Enzyme “systemic” support

• Use “systemic proteolytic enzymes” to support normal body processes.
• The three enzymes mentioned—nattokinase, serrapeptase, and lumbrokinase—are proteolytic (protein-digesting).
• The video describes them as supporting normal inflammation, circulation/immune function, and tissue repair by breaking down specific proteins.

Choose the enzyme based on your main goal

Rather than picking an enzyme for general “health,” the guidance is to match the enzyme to the desired outcome:

• Cardiovascular / blood-cleansing support (fibrin-focused)

  • Nattokinase and lumbrokinase: described as supporting normal cardiovascular function by helping with excess fibrin (clot/scar-tissue related protein).
  • Serrapeptase: framed as having “blood cleansing benefits,” but positioned more strongly for tissue recovery.

• Acute inflammation, injury/surgery-related issues, aches/pains

  • Serrapeptase: positioned as best for acute issues, including post-surgery/injury and inflammatory support.

• Sinus congestion and mucus/phlegm decongestion

  • Serrapeptase: described as breaking down mucin to help liquefy mucus, functioning like a “natural decongestant.”

Timing guidance

• Enzymes are typically recommended on an empty stomach, as stated in the video.

Dosage ranges (unit-focused)

Note: The ranges below are based on what’s stated in the subtitles/video discussion; they may not match every label.

• Nattokinase

  • Commonly reported effective range: 4,000–20,000 fibrinolytic units per day
  • The speaker claims higher amounts have been tried (“2–4× higher”) without issues.

• Lumbrokinase

  • Dosage not clearly specified in the provided subtitles.

• Serrapeptase

  • Minimum suggested: 100,000 serrapeptase units (SPUs) per day
  • Higher ranges observed: 4–6× that amount
  • International Units (IUs) note: product labels may use IUs instead of SPUs; the speaker suggests they’re likely still comparable to “units,” but advises checking with the manufacturer if unclear.

How to choose & how to pair (stacking guidance)

• Nattokinase + Serrapeptase together

  • Presented as a “gold standard” combination.

• Avoid combining lumbrokinase with other enzymes

  • The speaker claims lumbrokinase manufacturers warn against mixing it with other proteolytic enzymes because other enzymes may digest lumbrokinase, making it ineffective.
  • Because of this limitation, the speaker personally prefers nattokinase over lumbrokinase.

• Alternative: multi-enzyme formulas

  • Mentioned as a broad-spectrum strategy and described as a favorite approach by the speaker.
  • However, the lumbrokinase “don’t stack” restriction undermines this option if lumbrokinase is involved.

Safety framing

• Enzymes are described as supporting normal bodily functions rather than acting like drugs, implying overdose is “difficult” (as stated).
• Claims of safety appear throughout, especially for serrapeptase being discussed as “very safe.”

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What sets them apart (concise differentiation)

Nattokinase

• Source/production (speaker’s description)
  • Discovered in natto (fermented soy dish)
  • Produced during fermentation by Bacillus subtilis
  • Not found inside soy itself—soy is the starting protein substrate.
• Key use focus
  • Heart/cardiovascular support via excess fibrin cleansing, described as supporting normal blood/clotting balance.

Lumbrokinase

• Source/production (speaker’s description)
  • Extracted from earthworms grown in lab settings
  • Described as a group of ~7–20 enzymes (varies by product), not a single enzyme
  • Potential downsides claimed:
    • Possible GI side effects (e.g., nausea/vomiting) due to contamination risk
• Key use focus
  • Similar cardiovascular/fibrin focus as nattokinase, but highlighted practical downsides:
    • Higher price
    • Less clinical research claimed
    • Not recommended to be taken with other enzymes

Serrapeptase

• Source/production (speaker’s description)
  • Derived from a bacterium (e.g., Serratia sp./“ceratia E15” as stated)
  • Associated with silkworm digestion/skin environments; role is to break down silk for metamorphosis
  • Misconception addressed: it’s not made by silkworms, and does not contain silkworms in the enzyme itself.
• Key use focus
  • Damaged tissue / tissue repair + inflammation support
  • Pain and inflammation reduction, discussed via bradykinin
  • Mucus breakdown for congestion/decongestion support

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Presenters / sources

• Presenter: Danny Curtin
• Channel/brand referenced in subtitles: “Natural news” FAQs (referenced by the speaker; no separate individual source named)