The Treatment That Made Me 15 Years Younger

Summary

Dave Asprey interviews longevity physician Dr. Tim Cook about experimental treatments offered through their House of Evolution venture. The conversation focuses on three approaches: follistatin gene therapy, Klotho gene therapy, and immune-cell “reprogramming.” It also includes personal and client results reported by the speakers.

The treatments are described as costly and generally unavailable in the U.S. The interview is promotional, and the reported benefits should be understood as claims from the discussion—not established guarantees or routine medical advice.

Key wellness strategies and ideas discussed

Preserve muscle and improve body composition

Cook says aging can make it harder to build and maintain muscle, and argues that adequate protein and strength training can help. The speakers emphasize tracking body composition—not just weight—including muscle, total body fat, and visceral fat.

They report that some clients receiving follistatin gene therapy gained muscle and lost fat, including visceral fat. These are anecdotal or preliminary outcomes presented by the speakers.

Follistatin gene therapy

The treatment is described as a small circular DNA construct intended to prompt cells to produce more follistatin, a protein associated with muscle and bone maintenance. Asprey and Cook say it does not edit or integrate into a person’s genome and may remain active for roughly one to two years.

They report an average nine-year reduction in biological-age test results among participants, along with changes in muscle and fat. These are experimental claims; the interview does not establish long-term safety or effectiveness.

Klotho gene therapy

Klotho is discussed as a protein associated by the speakers with kidney function, cognition, libido, and aging. They describe preliminary results showing increased Klotho levels after treatment, including one person whose measured level rose substantially.

The speakers say the evidence is still limited and that the average effect on biological age is unknown.

Immune-cell and stem-cell reprogramming

The process described involves taking a person’s white blood cells and stem cells, incubating them near cord-blood stem cells so they can exchange signals, and returning the person’s own cells.

Asprey reports that his measured “immune age” was 15.2 years younger a few months after treatment. Cook also describes cases involving autoimmune conditions, but the discussion does not establish this treatment as a proven cure. The speakers stress that the cord-blood cells are used for signaling and are not infused into the patient.

Everyday health practices mentioned

• Prioritize sufficient protein and sensible strength training to support muscle.
• Pay attention to gut health and food sensitivities. Asprey discusses avoiding gluten when it worsens symptoms and suggests that gut health may affect immune function.
• The speakers mention low-dose naltrexone and PEA in the context of autoimmune conditions. These should be discussed with a qualified clinician rather than treated as general self-care advice.
• They describe biomarker testing and follow-up as ways to track health changes, while noting that biological-age and lifespan estimates are based on measurements and models.

Future possibilities

Asprey and Cook discuss collecting and storing a person’s stem cells for possible future genetic reprogramming, as well as growing tissue from stem cells. These are presented as developing technologies, not established options for general use.

Promotional segments

• The episode advertises OneSkin’s OS-01 face cream, citing results from a company clinical study on skin hydration and elasticity.
• It also advertises Mod’s modafinil product as supporting alertness and focus. This is a sponsor message, not a general productivity recommendation.

Presenters and sources mentioned

• Presenters: Dave Asprey and Dr. Tim Cook
• Organizations and products discussed or promoted: House of Evolution, Unlimited Life, MiniCircle, OneSkin, and Mod
• Other source mentioned: Asprey’s book Superhuman