Summary of "Hitman: Patient Zero Requiem - The Curious Case of Milla Jovovich and the Banana"

Hitman: Patient Zero — Requiem (Many A True Nerd)

Context: IO Interactive merged Hitman 1–3 into Hitman: World of Assassination and has been reusing/redressing existing maps to create new missions. Patient Zero (2017) introduced an infection mechanic; Patient Zero: Requiem is a direct callback/sequel that reuses that concept.
Premise: The celebrity elusive target (Milla / Millie Jovovich) plays Lilith Devo, a cultish executive who infects herself with a virus called Nightshade and attempts to spread it at an Ether fundraiser held in Dartmoor Manor. Agent 47 must stop the outbreak and eliminate Devo in a one-shot elusive-target run.
Tone: A heavy Resident Evil pastiche — underground labs, an AI named Herb, laser traps, an infection that spreads by proximity, and a theatrical villain speech.

“A cinematic, theatrical mission that mixes stealth assassination with infection-containment and Resident Evil-style puzzles.”

Elusive target rules: one attempt per run (you can restart only if you haven’t taken the final shot), so planning and a dry run are recommended.
Infection mechanic: the virus spreads via proximity — infected NPCs must be contained or killed; infection can rapidly escalate if not handled early.
Level design: redress of the Dartmoor Manor map. Knowledge of that level helps; the lab area has no mini-map icons, making stealth riskier.
Underground lab & puzzles: secret door under the manor (ring/key items, elevator), AI companion/antagonist (Herb), laser traps and platform dodges in the lab sequence.
Crafting/antidote system: find herbs in the greenhouse, combine them at a crafting station (green/blue herb mechanic) to make injectable cures, cure grenades, a cure gun and darts.
Cure vs kill: you can cure infected NPCs with antidote (useful to contain spread). You can cure the primary target to interrupt her plan before eliminating her if needed.
Stealth and environmental play: disguises, distractions (coins), lockpicks, lure-and-subdue, environmental kills (balconies, boxes), and improvised traps all matter.
Quality-of-life: map familiarity helps because the mission reuses Dartmoor Manor, but the lab’s lack of map icons increases risk.

Stage 0 — Recon / dry run
- Walk the map first to learn patrols and where the library/secret areas are.
- Observe Devo’s routine (she drinks from a glass, attends a secret meeting, later enters the lab).
Stage 1 — Get a useful disguise
- Distract a guard with coins, pull him to an isolated balcony, subdue and take his bodyguard/security disguise to access restricted areas.
- Alternatively, use external guards/disguises found outside for freer movement.
Stage 2 — Access secret areas and gather keys
- Enter the graveyard, dig up the corpse to recover the Carlile ring (used to access special areas).
- Use a side door into the library to reach the hidden elevator down into the lab.
Stage 3 — Secure the antidote
- Find Zachary’s room / lab and the herbs (green/blue herbs). Craft injectable antidote and cure ammo (cure gun/darts).
- Make multiple doses/darts if infection is likely to spread.
Stage 4 — Contain the outbreak
- Cure yourself first if infected (injectable/craftable cure).
- Use the cure gun / darts to disinfect infected NPCs from range so they stop spreading infection.
- Isolate or hide bodies in cupboards/boxes to avoid detection after subduing people.
Stage 5 — Deal with Lilith Devo
- Either cure Devo first to stop the spread, then eliminate her, or use stealth lethal methods once containment is managed.
- Environmental kills (pushing off a balcony, etc.) are viable but watch for witnesses and elusive-target constraints.

Contingencies

If you’re spotted early, restart before taking the final shot — do a recon attempt first to learn behaviors.
Prepare plenty of cure darts; the infection spreads quickly and can create many new targets.

Do a test run to learn Devo’s pathing and which doors become restricted; this helps prepare cures and disguises before lockdown.
Collect herbs from the greenhouse early so you can craft antidotes as soon as the lab is accessible.
Use coins and environmental distractions to separate guards and create isolated opportunities for subduing them.
Prioritize crafting the cure gun/darts — they let you deal with infected NPCs without causing chaos.
Beware the lab’s lack of map icons (no mini-map there) — move cautiously.
The mission is themed and a bit absurd (banana experiment, Resident Evil nods); don’t expect a traditional Silent Assassin clean-run — the infection and manor security can rapidly escalate chaos.
Note: there is small paid cosmetic/premium content tied to the mission (microtransactions / tiny battle-pass items like a “multi-pass” inspired cosmetic).

Strong Resident Evil homage: virus lab, AI Herb, lasers, herb crafting.
The mission is a redress of Dartmoor Manor and expands on the Patient Zero concept with a celebrity elusive target.
Milla / Millie Jovovich’s Lilith Devo leans into her Resident Evil film persona, playing a cultish villain rather than herself.
The video includes comedic experiments (banana peel) and the host’s commentary on IO’s recent mission design trends (celebrity targets, frequent redresses).