MLB Picks Today 9/25/2026 | MLB Best Bets, Predictions, and Player Props Friday September 25 2026

Overview

This video is a Friday MLB betting preview for September 25, 2026, covering 17 games plus two doubleheaders. The host breaks down matchups and provides betting leanings for moneyline, run line, and alternate totals / game totals—often favoring “under” due to weather/wind considerations. The discussion also touches on playoff implications, including wild-card and division seedings.

---

Key games and picks (chronological)

Red Sox vs. Cubs — Doubleheader (Game 1)

• Playoff context: Cubs’ result matters more than Boston’s.
• Pitchers mentioned: Clay Holmes vs. Alex Gamboa
• Pick: Cubs (moneyline)
• Total lean: Under (around 6.5), citing weather/wind and concern pitchers won’t get “crushed.”

---

Yankees vs. Orioles — Doubleheader (Game 1)

• Pitchers mentioned: Trevor Rogers vs. Braden Beck
• Pick: Orioles (Baltimore)
  • Rationale includes the Yankees managing risk late in the season.
• Total lean: Under (around 6.5), despite strong Yankees bats.

---

Red Sox vs. Cubs — Doubleheader (Game 2)

• Pitchers mentioned: Brian Bello vs. David Peterson
• Pick: Again Cubs
• Total lean: Under (noted as < 6.5), expecting low-scoring outcomes (examples: 4–2 / 3–2).

---

Tigers vs. Pirates

• Pitchers mentioned: Jackson Jobe vs. Bubba Chandler
• Pick: Pirates
  • Host expects a close game and thinks Chandler has the edge.
• Run/walk angle: Walks are highlighted as a key prop-like factor—Tigers could benefit if Chandler walks hitters—but the main lean remains Pittsburgh.
• Total lean: Less of a confident full-game total; discussion focuses more on wind, right-field impact, and lefty/righty factors, with attention shifting toward potential scoring scenarios.

---

Phillies vs. Rays

• Pitchers mentioned: Chris Sanchez vs. Freddy Peralta
• Pick: Phillies
  • Host calls Sanchez a major edge in an important playoff-relevant spot.
• Total lean: Host avoids betting the overall game total, preferring not to “trust Tampa Bay” against Sanchez, with an implication that Phillies run production may be stronger.

---

Nationals vs. Mets

• Pitchers mentioned: Andrew Alvarez vs. Jonathan Pintaro
• Pick: Nationals
  • Host notes concerns about Mets’ starter versus left-handers (as framed by the host).
• Bet type: Mentions possibly an alternate (like Nationals moneyline) rather than an over, due to weather risk.

---

Yankees vs. Orioles — Doubleheader (Game 2)

• Pitchers mentioned: Orioles starter Brendan Young (Yankees starter not confirmed in narration)
• Pick: Host expects to lean Orioles again
  • Same general theme: managing risk / positioning as the underdog.
• Total: Not clearly stated as a fixed number here.

---

Blue Jays vs. Reds

• Pitchers mentioned: Jose Soriano vs. Nick Lodolo
• Pick: Blue Jays
  • Based on team strength plus pitching/matchup concerns for Lodolo.
• Possible alt ideas (exploratory):
  • Soriano-style under concept (framed around less than 2.5 “missed runs”)
  • Even mentions Reds early-inning under concepts, presented as more of an experiment.

---

Giants vs. Dodgers

• Pitchers mentioned: Tariq Skubal vs. Yu Marte
• Pick: Giants under on total
  • Host expects Skubal to have a good game and not much offense.
• Strikeouts/innings discussion: Mentions a strikeout line near 17.5 and speculates Skubal working around six innings.

---

Marlins vs. Braves

• Pitchers mentioned: Yerry Perez vs. Grant Holmes
• Pick: Host leans Braves
  • Notes Miami could win, but expects Braves to be ready for the playoffs and leans toward “more runs / over-support” logic relative to other games.
• Total lean: More over-oriented than most other games in the video.

---

Royals vs. Guardians

• Pitchers mentioned: Noah Cameron vs. Gavin Williams
• Pick: Guardians (moneyline)
• Total lean: Expects a low-scoring game (with references to results like 1–0).

---

White Sox vs. Rockies

• Pitchers mentioned: Sean Burke vs. Tomoyuki Sugano
• Pick: White Sox to win
• Total/alt lean:
  • Prefers under in the first five innings
  • Also suggests under is possible if Burke pitches well.
• Reasoning: Host wants to back Burke (walks/strikeouts mentioned), but says it’s not straightforward.

---

Brewers vs. Cardinals

• Pitchers mentioned: Robert Gasser vs. Michael McGreevy
• Pick: Host discusses pricing/value and leans Cardinals, not viewing them as a longshot
  • Mentions the plus price should be lower than advertised.
• Total lean: Still leans under on totals.

---

Twins vs. Rangers

• Pitchers mentioned: deGrom vs. Joe Ryan
• Pick: Rangers
  • Framed as important division positioning.
• Run line: Texas mentioned as a run-line option.
• Total lean: Under, with emphasis that the Texas side is the more confident bet.

---

Padres vs. Diamondbacks

• Pick: Host likes under betting
  • Expects both starters to keep things controlled early.
• Context: Both teams still “care” about playoff positioning; host mentions Padres’ recent form (including sweeps and strong run).

---

Astros vs. Athletics

• Pitchers mentioned: Hunter Brown
• Pick: Host likes Astros
  • Calls it the primary interest due to “staying alive” in the playoff race.
• Total lean: Under (including an “under/under” style approach).

---

Mariners vs. Angels

• Pitchers mentioned: Reed Detmers vs. Bryce Miller
• Pick: Host is not excited about the Angels side at the given price.
• Total lean: Prefers a low-scoring angle
  • Mentions possible under in first three innings
• Game total reference: Around 6.5 is referenced.

---

Presenters / sources (end of video)

• The host / channel (unnamed in subtitles)
• Chalkboard
  • Ad/affiliate mention including promotions and a code: “Guy Boston”
• Bucketsandbucks.com
  • Referenced for division standings/logic